Clinical Research

When we say science-backed supplements, we mean it. Here is a list of all the human clinical science that was referenced in the formulation of our products.

KSM-66 Ashwagandha

KSM-66 Ashwagandha

Sexual Function and Testosterone Levels in Men: Yields significant increase in semen volume, sperm concentration and motility, serum LH and testosterone.

  • Mahdi AA, Shukla KK, Ahmad MK, et al. Withania somnifera Improves Semen Quality in Stress-Related Male Fertility. Evidence-based Complementary and Alternative Medicine : eCAM. 2011;2011:576962.

Muscle Strength, Muscle Size, Muscle Recovery and Testosterone: Found to be effective in healthy athletic adults in improving maximum resistance load, muscle recovery and key hormone levels.

  • Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr Journal of the International Society of Sports Nutrition. 2015;12(1).

Energy and Stamina: Athletes taking KSM-66 showed substantially higher improvement in cardiorespiratory endurance (VO2max) and self-assessed scores on the WHO Quality of Life Questionnaire.

  • Choudhary B, Shetty A, Langade DG. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu. 2015;36(1):63-68.

Cognition and Memory: Statistically significant improvement in key components of Wechsler Memory Scale, executive function and attention using KSM-66.

  • Choudhary D, Langade D. Efficacy and Safety of an Ashwagandha (Withania somnifera) Root Extract in Improving Memory and Selected Cognitive Functions.

Stress, Weight Management and General Well-Being: Reduced stress confirmed via lower stress scale responses, cortisol levels and BMI, and improved score on the Oxford Happiness Scale.

  • Choudhary D, Bhattacharyya S, Joshi K. Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. J Evid Based Complementary Altern Med. 2016 Apr 6.

Anxiety Reduction and Stress Relief: Achieves a highly significant reduction in stress and anxiety, and serum cortisol levels (27.9% reduction).

  • Chandrasekhar K, Kapoor J, Anishetty S. A Prospective, Randomized Double-Blind, Placebo- Controlled Study of Safety and Efficacy of a High- Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. Indian J Psychol Med. 2012 Jul;34(3):255-62.

* PLEASE CONTACT INFO@IXOREAL.COM FOR MORE INFORMATION ON ONGOING STUDIES, PUBLISHED PAPERS AND TECHNICAL REPORTS ON KSM-66.


American Ginseng

American Ginseng

Increases mental clarity: Supplementation is associated with improved delay recall, delayed recognition, and face recognition tests.

  • Mix JA, Crews WD Jr. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings. Hum Psychopharmacol. 2002 Aug;17(6):267-77.

Reduces mental stress and anxiety: Supplementation was associated with less anxiety symptoms as assessed by the HAMA rating scale – and stress-induced increases in blood pressure and cortisol appear to be attenuated.

  • Woelk H, Arnoldt KH, Kieser M, Hoerr R. Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. J Psychiatr Res. 2007 Sep;41(6):472-80. Epub 2006 Jun 30.
  • Jezova D, Duncko R, Lassanova M, Kriska M, Moncek F. Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb 761) in healthy volunteers. J Physiol Pharmacol. 2002 Sep;53(3):337-48.

Cordyceps Mushroom

Cordyceps Mushroom

Therapeutic Benefits: The far-reaching benefits are hypothesized to include “increased oxygen utilization, increased ATP production, and the stabilization of blood sugar metabolism.” Significant clinical studies are still underway.

  • Holliday J, Cleaver M. The Medicinal Value of the Caterpillar Fungi Species of the Genus Cordyceps (Fr.) Link (Ascomycetes). International Journal of Medicinal Mushrooms 10(3):219-234. December 2007.

Tongkat Ali (Longjack)

Tongkat Ali (Longjack)

Sexual Enhancer: An increase in libido is seen with prolonged daily ingestion of eurycoma supplements.

  • Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1.

Supports Male Fertility: Supplementation found erectile and libido increased, along with general improvement of well being in otherwise healthy men.

  • Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1.

Tribulus Terrestris

Tribulus Terrestris

Libido: This supplement appears to possess aphrodisiac activity probably due to androgen increasing property

  • Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sci. 2002 Aug 9;71(12):1385-96.

Male Fertility: Increases some of the sex hormones, possibly due to the presence of protodioscin in the extract, and may be useful in mild to moderate cases of ED. Another study confirms the proerectile aphrodisiac property of TT by measuring the increase in intracavernous pressure.

  • Phytomedicine. 2008 Jan;15(1-2):44-54. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction–an evaluation using primates, rabbit and rat.
    Gauthaman K1, Ganesan AP.
  • Kalamegam Gauthaman, Adaikan P. Ganesan, and R. N. V. Prasad. Sexual Effects of Puncturevine (Tribulus terrestris) Extract (Protodioscin): An Evaluation Using a Rat Model. The Journal of Alternative and Complementary Medicine. July 2004, 9(2): 257-265. doi:10.1089/10755530360623374.

Cancer Fighting: Extract of TT exhibited remarkable activity against fungal organisms (Candida albicans and Cryptococcus neoformans) and cancer cell lines.

  • Bedir E , Khan IA , Walker LA. Biologically active steroidal glycosides from Tribulus terrestris. National Center for Natural Products Research, University of Mississippi, USA. Die Pharmazie [2002, 57(7):491-493].

Siberian Eleuthero

Siberian Eleuthero

Endurance & Energy: Possibly effective at increasing cardiovascular exercise performance. May increase physical performance.

  • Asano K, Takahashi T, Miyashita M, Matsuzaka A, Muramatsu S, Kuboyama M, Kugo H, Imai J. Effect of Eleutherococcus senticosus extract on human physical working capacity. Planta Med. 1986 Jun;(3):175-7.
  • Kuo J1, Chen KW, Cheng IS, Tsai PH, Lu YJ, Lee NY. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human. Chin J Physiol. 2010 Apr 30;53(2):105-11.

Immunity & General Wellness: Appears to have a stimulating effect on T-cell proliferation and NK cell activity.

  • Szołomicki J1, Samochowiec L, Wójcicki J, Droździk M. The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytother Res. 2000 Feb;14(1):30-5.
  • Bohn B1, Nebe CT, Birr C. Flow-cytometric studies with eleutherococcus senticosus extract as an immunomodulatory agent. Arzneimittelforschung. 1987 Oct;37(10):1193-6.

Stress Resistance: Reduces cardiovascular responses to stress in healthy young volunteers. Confirmed to be helpful for stress adaptation.

  • Facchinetti, F., Neri, I. and Tarabusi, M. (2002), Eleutherococcus senticosus reduces cardiovascular stress response in healthy subjects: a randomized, placebo-controlled trial. Stress and Health, 18: 11–17. doi: 10.1002/smi.914

Horny Goat Weed

Horny Goat Weed

Male Libido & Sexual Function: Supplementation shows improved erectile function. The active ingredient is suggested to be icariin, which has been shown to be effective in inhibiting human PDE5, the substance that blocks erections.

  • Shindel AW, Xin Z-C, Lin G, et al. Erectogenic and Neurotrophic Effects of Icariin, a Purified Extract of Horny Goat Weed (Epimedium spp.) In Vitro and In Vivo. The journal of sexual medicine. 2010;7(4 Pt 1):1518-1528.
  • Corazza O, Martinotti G, Santacroce R, et al. Sexual Enhancement Products for Sale Online: Raising Awareness of the Psychoactive Effects of Yohimbine, Maca, Horny Goat Weed, and Ginkgo biloba. BioMed Research International. 2014;2014:841798.
  • Shindel AW, Xin Z-C, Lin G, et al. Erectogenic and Neurotrophic Effects of Icariin, a Purified Extract of Horny Goat Weed (Epimedium spp.) In Vitro and In Vivo. The journal of sexual medicine. 2010;7(4 Pt 1):1518-1528.

English Hawthorn Berry

English Hawthorn Berry

Healthy Heart: Hawthorn extract appears to be anti-arrhythmic and capable of inducing rhythmicity in quiescent cardiomyocytes. Beneficial treatment in heart failure.

  • S.R. Long, R.A. Carey, K.M. Crofoot, P.J. Proteau, T.M. Filtz. Effect of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay. Phytomedicine, Volume 13, Issues 9–10, 24 November 2006, Pages 643–650.
  • Corder R, Warburton R, Khan N, Brown R, Wood E, Lees D. The procyanidin-induced pseudo laminar shear stress response: a new concept for the reversal of endothelial dysfunction. Clinical Science Nov 01, 2004, 107 (5) 513-517; DOI: 10.1042/CS20040189
  • Degenring FH1, Suter A, Weber M, Saller R. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II. Phytomedicine. 2003;10(5):363-9.

Blood Pressure for Diabetics: Early findings support that hawthorn supplementation lowers blood pressure in patients with diabetes taking medication.

  • Walker AF, Marakis G, Simpson E, et al. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. The British Journal of General Practice. 2006;56(527):437-443.

Premium Neptune Krill Oil (NKO®)

Premium Neptune Krill Oil (NKO®)

Reduce Arthritis: Found to reduce symptoms of osteoarthritis up to 30%, which is a pretty significant effect size.

  • Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr. 2007 Feb;26(1):39-48.

Reduce Inflammation: A decrease in C-Reactive protein has been noted in rheumatoid arthritis – reached 30% within 30 days of 500mg krill oil, a very significant reduction.

  • Ulven SM, Kirkhus B, Lamglait A, Basu S, Elind E, Haider T, Berge K, Vik H, Pedersen JI. Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. Lipids. 2011 Jan;46(1):37-46. doi: 10.1007/s11745-010-3490-4. Epub 2010 Nov 2.
  • Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr. 2007 Feb;26(1):39-48.

Improved Cholesterol: A decrease in total cholesterol has been noted with krill oil, to a fairly normal degree. Increased HDL cholesterol (the “good” cholesterol) – remarkable in that it exceeded 50%. Decreased LDL cholesterol (the “problem” cholesterol), which appears to be to quite a significant degree.

  • Ulven SM, Kirkhus B, Lamglait A, Basu S, Elind E, Haider T, Berge K, Vik H, Pedersen JI. Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. Lipids. 2011 Jan;46(1):37-46. doi: 10.1007/s11745-010-3490-4. Epub 2010 Nov 2.
  • Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr. 2007 Feb;26(1):39-48.

Female Wellnes: PMS and its symptoms (breast tenderness, stress, and irritability mostly) have been reduced with krill oil supplementation.

  • Sampalis F, Bunea R, Pelland MF, Kowalski O, Duguet N, Dupuis S. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev. 2003 May;8(2):171-9.

CoQ10

CoQ10

Healthy Heart and Circulation: Appears to increase blood flow in metabolic conditions characterized by both insufficient blood flow and an excess of oxidative stress.

  • Lee YJ1, Cho WJ, Kim JK, Lee DC. Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study. J Med Food. 2011 Apr;14(4):386-90. doi: 10.1089/jmf.2010.1202. Epub 2011 Mar 3.
  • Watts GF1, Playford DA, Croft KD, Ward NC, Mori TA, Burke V. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia. 2002 Mar;45(3):420-6.

Increased male fertility: Some beneficial influences on the sperm quality in men.

  • Safarinejad MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol. 2009 Jul;182(1):237-48. doi: 10.1016/j.juro.2009.02.121. Epub 2009 May 17.

Lutein

Lutein

Protects Eyes: Lutein and structurally related carotenoids are known to accumulate in the eye where they can buffer light and protect underlying retinal cells from oxidative stress.

  • Junghans A1, Sies H, Stahl W. Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. Arch Biochem Biophys. 2001 Jul 15;391(2):160-4.

Vitamin D3

Vitamin D3

Stronger Bones and Reduced Falls: An improvement in muscular and neural functionality in the elderly is thought to underlie the reductions of fall risk and reduced bone fracture rate seen in elderly cohorts.

  • Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med. 2009 Mar 23;169(6):551-61. doi: 10.1001/archinternmed.2008.600.
  • Sato Y1, Iwamoto J, Kanoko T, Satoh K. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Cerebrovasc Dis. 2005;20(3):187-92. Epub 2005 Jul 27.